In laboratory studies at Cincinnati Children's Hospital Medical Center, researchers have successfully treated the most common malignant abdominal tumor of childhood: neuroblastoma tumors. Researchers successfully treated the tumor in mouse models by administering a treatment based on a weakened version of the herpes simplex virus.
Neuroblastomas are solid cancerous tumors that usually begin in the nerve tissues of the adrenal gland, but may also begin in the nerve tissues of the neck, chest or pelvis. These are solid cancerous tumors that are diagnosed in approximately 650 children in the United States each year, and most of these children are diagnosed before age five. In 70 percent of these cases, the cancer will have metastasized, or spread to other areas of the body.
Researchers tested two treatment protocols: the adenovirus, a virus often associated with the common cold; and, a weakened version of herpes simplex virus, which is most commonly associated with cold sores. Only the herpes simplex virus proved to be effective in treating neuroblastoma tumors, said Timothy Cripe, MD, PhD, director of the Comprehensive Musculoskeletal Tumor Clinic and Translational Research Trials Office at Cincinnati Children's and senior author of the new study. [EurekAlert! - Medicine and Health]