Black Tea Polyphenols May Inhibit Hormone-dependent Breast Tumors

"The aromatase enzyme, which converts androstenedione to estrone, regulates the availability of estrogen to support the growth of hormone-dependent breast tumors. In this study, we investigated the inhibitory effects of black tea polyphenols on aromatase activities," reported T.D. Way and colleagues, National Taiwan University. "We found that black tea polyphenols, TF-1, TF-2, and TF-3, significantly inhibited rat ovarian and human placental aromatase activities. In addition, using an in vivo model, these black tea polyphenols also inhibited the proliferation induced by 100 nM dehydroepiandrosterone (DHEA) in MCF-7 cells," the researchers said. They also noted that "transfection of HER2/neu in MCF-7 breast cancer cells appeared to... [Cancercompass News: Cancer Nutrition]

Posted December 2004 | Permanent Link


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